This appears to have a positive impact on the lifespan, since inhibition of S6 kinase improves longevity in yeast, nematodes, flies, and mice [10,15,22]. In C. elegans, DAF-16 plays an essential role in longevity related to inhibition of the insulin/IGF-1 pathway [23,24], while inhibition of TOR extends the lifespan independently of DAF-16 [17,25]. In mammals, however, the role of TOR in longevity
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